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pentobarbital will lessen the extent or influence of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay clear of use in sufferers who will be chronically employing a robust CYP3A4 inducerIn decades previous, barbiturates were a